Publications
A Multicomponent Reaction-Based Platform Opens New Avenues in Aryl HydrocarbonReceptor Modulation.
P. Nadal Rodríguez, † F. Hartung, † M. Pedrola, S. Coomar, A. Diaz-Moreno, A. M. Hätälä, K. M. Rolfes, I.Sánchez-Vera, J. Gil, E. Molins, A. Viayna, A. Hanzl, N. H. Thomä, T. Haarmann-Stemmann,* F. J.Luque,* R. Lavilla* and O. Ghashghaei*
ACS Cent. Sci. 2025, 11, 629–641
DOI: 10.1021/acscentsci.5c00194
Drugs from Drugs: New Chemical Insights into a Mature Concept.
E. Lozano Baró, F. Catti, C. Estarellas, O. Ghashghaei* and R. Lavilla*
Drug Discov. Today 2024, 29, 104212
DOI: 10.1016/j.drudis.2024.104212
Nonperturbative Fluorogenic Labeling of Immunophilins Enables the Wash-Free Detection of Immunosuppressants
M. Bertolini, L. Mendive-Tapia, O. Ghashghaei, A. Reese, C. Lochenie, A. M. Schoepf, M. Sintes, K. Tokarczyk, Z. Nare, A. D. Scott, S. R. Knight, A. R. Aithal, A. Sachdeva, R. Lavilla* and M. Vendrell*
ACS Cent. Sci. 2024, 10, 969–977
DOI: 10.1021/acscentsci.3c01590
Reaction Space Charting as a Tool in Organic Chemistry Research and Development
E. Lozano Baró,† P. Nadal Rodríguez,† J. Juárez-Jiménez, O. Ghashghaei* and R. Lavilla*
Adv. Synth. Catal. 2024, 366, 551–573
DOI: 10.1002/adsc.202301205
Charting the Chemical Reaction Space around a Multicomponent Combination: Controlled Access to a Diverse Set of Biologically Relevant Scaffolds
P. Nadal Rodríguez, O. Ghashghaei*, A. M. Schoepf, S. Benson, M. Vendrell and R. Lavilla*
Angew. Chem. Int. Ed. 2023, 62, e202303889
DOI: 10.1002/anie.202303889
Efficient AntiMycolata Agents by Increasing the Lipophilicity of Known Antibiotics through Multicomponent Reactions
A. Trejo, C. Masdeu, I. Serrano-Pérez, M. Pedrola, N. Juanola, O. Ghashghaei, G. Jiménez-Galisteo, R. Lavilla*, F. Palacios, C. Alonso* and M. Viñas*
Antibiotics 2023, 12, 83
DOI: 10.3390/antibiotics12010083
The Prohibitin-Binding Compound Fluorizoline Activates the Integrated Stress Response through the eIF2α Kinase HRI
I. Sánchez-Vera, S. Núñez-Vázquez, J. Saura-Esteller, A. M. Cosialls, J. Heib, P. Nadal Rodríguez, O. Ghashghaei, R. Lavilla, G. Pons, J. Gil* and D. Iglesias-Serret*
Int. J. Mol. Sci. 2023, 24, 8064
DOI: 10.3390/ijms24098064
The Prohibitin-Binding Compound Fluorizoline Induces the Pro-inflammatory Cytokines Interleukin-8 and Interleukin-6 through the Activation of JNK and p38 MAP Kinases
I. Sánchez-Vera, J. Saura-Esteller, S. Núñez-Vázquez, A. M. Cosialls, O. Ghashghaei, R. Lavilla, G. Pons, J. Gil and D. Iglesias-Serret*
Biochem. Pharmacol. 2023, 216, 115860
DOI: 10.1016/j.bcp.2023.115860
Heterocycles as Inputs in MCRs: An Update
O. Ghashghaei, M. Pedrola, C. Escolano and R. Lavilla*
In Multicomponent Reactions toward Heterocycles; Wiley-VCH, 2022
DOI: 10.1002/9783527832439.ch1
Funding
